Cancer Detection and Prevention Volume 19 / Issue 4 (Jul-Aug 1995)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Gender-Related Differences in the Distribution of Thoracic Versus Abdominal Malignant Mesothelioma

Ralph J Delfino, M.D., Ph.D., Hoda Anton-Culver, Ph.D., Sidney L Saltzstein, M.D., M.P.H.

The proportion of thoracic malignant mesotheliomas (MM) was higher in males than in females. There was no gender difference for rates of abdominal MM. In both sexes the mean age was higher for thoracic MM than for abdominal MM. >>>

Varying Effect of Dietary Lipids and Azoxymethane on Early Stages of Colon Carcinogenesis: Enumeration of Aberrant Crypt Foci and Proliferative Indices

Ranjana P Bird, Ph.D., Lynne MZ Lafave

In Sprague-Dawley male rats a low dose of azoxymethane (AOM) produced fewer aberrant crypt foci (ACF) and larger crypts than injection of a higher dose. A low (00) or high (H00) olive oil diet with a low dose of AOM produced a lower number of ACF than low (CO) or high (HC0) corn oil feeding. With a high dose of AOM a diet of HCO produced more ACF than CO. >>>

Detection of Human Cytomegalovirus in Female and Male Anogenital Lesions with Papillomavirus-Associated Dysplastic Changes

Christiane Mougin, M.D., Ph.D., Catherine Bernard, Ph.D., Jean Patrick Schaal, M.D., Ph.D., Rene Laurent, M.D., Ph.D., Jean Pierre Carbillet, M.D., Ph.D., Michel Lab, M.D., Ph.D.

In situ hybridization of biopsies from anogenital lesions of 198 women and 55 men revealed intranuclear human papilloma virus (HPV)-DNA in 40 percent of low-grade squamous intraepithelial lesions (SIL) and in 95 to 100 percent of lesions with high-grade SIL. Cytomegalovirus (CMV) nucleic acid sequences in 30 percent of females and in 16 percent of males were mainly associated with high-grade SIL. >>>

A DNA Probe Study on the Origin of the Cancer Recognition, Immunedefense Suppression and Serine Protease Protection Peptide

Lea Cercek, Ph.D., Martin Siaw, Ph.D., Bibijana Cercek, Ph.D., Boris Cercek, D.Sc

Use of quantitative "two DNA probe" dot hybridization assay demonstrated in cancer cells the production of the cancer recognition, immune defense suppression, and serine protease protection (CRISPP) peptide in addition to alpha 1=P1 molecules. It is suggested that detection of the CRISPP peptide DNA regions by use of the two DNA probe may offer a useful adjunct for cancer diagnosis in biopsies and for predictive diagnosis in familial cancers. >>>

Usefulness of Coagulation Markers in Staging of Gastric Cancer

Vincenzo Abbasciano, M.D., Davide Tassinari, M.D., Sergio Sartori, M.D., Lucio Trevisani, M.D., Diego Arcudi, M.D., Maria P Bianchi, Ph.D., Alberto Liboni, M.D.

Thirty-six patients with nonmucinous adenocarcinoma of the stomach failed to reveal any coagulation impairment. Beta-thromboglobulin did not show significant differences between localized and extended gastric cancer. Elevated levels of platelet factor four were related to local invasiveness, lymph node involvement and spread to distant organs. >>>

Flexible Sigmoidoscopy Or Colonoscopy for Colorectal Screening: A Randomized Trial of Performance and Acceptability

J Mark Elwood, M.D. , Galeb Ali, M.B., Martin MT Schlup, M.D., Bronwen McNoe, B.H. SC., Gilbert 0 Barbezat, M.D. Fiona North, Ph.D., Kensie Sutton, R.N., Bryan Parry, M.D., Vinton S. Chadwick, M.D.

In a randomized clinical trial of 137 asymptomatic individuals with family history of colorectal carcinoma or adenoma and 95 subjects without a family history, 62 percent accepted instrumental screening for colorectal disease. The prevalence of polyps was 41 percent in those with a positive family history. Flexible sigmoidoscopy was found to be more uncomfortable and with greater after-effects than colonoscopy. Authors recommend colonoscopy as the first line of investigation. >>>

Influence of Different Combinations of Tamoxifen and Toremifene on Estrogen Receptor-Positive Breast Cancer Cell Lines

Danila Coradini, Ph.D., Anna Biffi, Ph.D., Vera Cappelletti, Ph.D., Giovanni Di Fronzo, Ph.D.

Effects of different combinations and sequential treatments with tamoxifene and toremifene on human receptor-positive breast cancer cell lines revealed estrogenic activity with results suggesting inefficacy of the triphenylethylene derivatives as hormone treatment. >>>

Differentiation and Tumor Response to Retinobenzoic Acid Re-80 in a Malignant Conversion Model

Molly F Kulesz-Martin, Ph.D., Barbara Lisafeld, Joyce Paterson, M.D., Deborah Driscoll, B.A., Koichi Shudo, Ph.D., Dennis R Roop, Ph.D., Nicholas D Kisiel, M.S.

Papillomas and moderately differentiated squamous cell carcinomas were reduced in volume about four-fold as a result of treatment with the synthetic retinobenzoic acid RE-80. Larger, poorly differentiated squamous cell carcinomas remained unaffected. In 3 of 4 in vitro experiments RE-80 induced morphologic changes of enlarged cells with lower nuclear to cytoplasmic ratio and fewer cells per colony suggestive of differentiation. In in vivo studies of mice treated with RE-80, 5 of 6 tumors decreased in size. >>>

New Thermoluminescent baso(4):eu Sheet for in Vivo Measurement of Spatial Dose Distribution in Radiation Therapy

Kazuro Iwata, Ph.D., Hitoshi Yoshimura, M.D., Toshiaki Tamada, M.D., Hajime Ohishi, Hideo Uchida, M.D., Masuo Nakagawa, Ph.D., Kohl Utsunomiya, M.S., Isao Yamamoto, Ph.D., Tomonori Wada, Ph.D.

A sensitive thermoluminescent (TL) teflon sheet 40cm x 50cm x 0.2mm mixed with BaSO4 permits in vivo measurement of radiation distribution and protects healthy tissue from radiation damage in intracavity radiation therapy. The data processing in the TL sheet readout system is programmed by a computer interfacing with an image processor. >>>

T/Tn Antigen Vaccine is Effective and Safe in Preventing Recurrence of Advanced Breast Carcinoma

Georg F Springer, M.D., Parimal R Desai, Ph.D., Bruce D Spencer, Ph.D., Herta Tegtrneyer, Sheila C Carlstedt, Edward F Scanlon, M.D.

Intradermal vaccination with T/Tn antigen was used against recurrence of advanced breast carcinoma. Of 19 patients vaccinated, 3 patients died of cancer while 11 of 14 (79%) patients survived more than 10 years. Five others are alive but have not reached the ten-year threshold. >>>


Herbert E. Nieburgs, MD
Worcester, MA