Cancer Detection and Prevention Volume 19 / Issue 2 (Mar-Apr 1995)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Hereditary Medullary Thyroid Carcinoma

HFA Vasen, MD, PhD, A Vermey, MD, PhD, FACS

The review of hereditary medullary thyroid carcinoma (MTC) focuses on classification, clinical features and phenotypic expression associated with multiple endocrine neoplasias. Biochemical and genetic screening, surgical techniques and prognostic aspects are evaluated. >>>

Expression of the p53 Gene and Presence of Serum Autoantibodies in Ovarian Cancer: Correlation with Differentiation

JA, Green, B.Sc., D.M., F.R.C.P., LJ. Robertson, B.A., IR Campbell, M.B.Ch.B., F.R.C.R., J Jenkins, Ph.D.

Archival material from 105 ovarian cancer biopsies were examined for the presence of p53 protein by an immunoperoxidase technique using the cell-mediated immune antibody. Tissue expression of p53 in ovarian tumors, detected by serum autoantibodies correlated with moderate and poor histologic differentiation whereas negative staining was associated with well-differentiated tumors. >>>

Risk Factors and p53 Nuclear Overexpression in Early Stage Intestinal-Type Adenocarcinoma of the Stomach

Zuo-Feng Zhang, M.D., Ph.D., Martin S Karpeh, M.D., Gregory Y Lauwers, M.D., Arturo M Marrero, M.D., Daphna Pollack, M.P.H., Carlos Cordon-Cardo, M.D., Ph.D., Colin Begg, Ph.D.

Nuclear overexpression of p53 protein, assessed by immunohistochemistry using monoclonal antibody PAb1801 was present in 50% of patients with a negative family history of cancer against 31% of patients with a positive family history. In early stages of gastric cancer, p53 overexpression was higher in the intestinal type (43%) than in the diffuse type (23%) of adenocarcinoma. Overexpression of p53 was identified in 52% of patients who had a previous history of smoking as compared to 29% of patients who never smoked. >>>

Flow Cytometric Measurements of Deoxyribonucleic Acid Ploidy and Proliferative Activity for Evaluating Malignant Potential of Human Bladder Cancers

Ayako Miyakawa, M.D., Masaaki Tachibana, M.D., Hiroshi Tazaki, M.D.

The malignant potential of 100 untreated human urinary bladder transitional cell carcinomas was evaluated by flow cytometric DNA/bromodeoxyuridine analysis. A high bromodeoxyuridine-labeled index was associated with a 3 year survival in 38.1% of patients while a low index was present in 96.1 % of patients with the same survival period. In tumors with muscle invasion the bromodeoxyuridine-labeled cell index was 17.2 ± 8.5% against an index of 6.6 ± 5.2% in cases of superficial tumors. >>>

T/Tn Pancarcinoma Autoantigens: Fundamental, Diagnostic, and Prognostic Aspects

Georg F Springer, M.D., Parimal R Desai, Ph.D., M Ghazizadeh, M.D., Herta Tegtmeyer, M.T.

Cell-mediated autoimmune responses to T and Tn autoantigens were measured by delayed-type skin hypersensitivity to T(DTHR-T) and by solid-phase anti-T-antibody immunoassay (SPIA-T). DTHR-T was positive in 85% of 461 cancer patients and in 8% of 328 patients without evidence of cancer and was negative in 126 healthy persons. SPIA-T was positive in 88% of 222 patients with cancer. Positive anti-T tests were observed in 74% of 47 patients up to 8 years before positive biopsies and X rays. Consistently negative anti-T reactions in 37 individuals with suspicious lesions were not associated with cancer development within an average observation period of 4.7 years. The proportion of Tn epitopes was greater in undifferentiated breast carcinomas, while T epitopes predominated in the well-differentiated tumors. >>>

Usefulness of CEA, TPA, GICA, CA 72.4, And CA 195 in the Diagnosis of Primary Colorectal Cancer and At its Relapse

Andrea Nicolini, M.D., Marco Caciagli, M.D., Fabio Zampieri, M.D., Giorgio Ciampalini, M.D., Angelo Carpi, M.D., Roberto Spisni, M.D., Cesare Colizzi, M.D.

Serial follow-up analyses of colorectal cancer patients by post operative serum levels of carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and gastrointestinal cancer antigen (GICA) permitted identification of micrometastases. The sensitivity for detection of recurrence was 87% for TPA and 93% for the combina of TPA and GICA. >>>

Perinatal Transmission and Maternal Risks of Human Papillomavirus Infection

Elaine M Smith, M.P.H., Ph.D., Susan R Johnson, M.D., Timothy Cripe, M.D., Ph.D.,, Stanley Perlman, M.D., Ph.D., Gail McGuinness, M.D., Donald Jiang, M.S., Linda Cripe, M.D., Lubomir P Turek, M.D.

The rate of vertical HPV transmission to neonates from 203 pregnant women was one percent. This low transmission rate was possibly due in part to the fact that 65% of HPV-positive mothers during the third trimester tested HPV-negative at delivery. >>>

Effect of the Cancer Recognition, Immunedefense Suppression, And Serine Protease Protection Peptide on DNA

Lea Cercek, Ph.D., Brian I Carr, M.D., Ph.D., Martin Siaw, Ph.D., Boris Cercek, D.Sc.

The cancer recognition, immunodefense suppression and protease protection (CRISPP) peptide enhanced DNA synthesis in cultured red hepatocytes and human peripheral blood lymphocytes. In hepatocytes that were stimulated by epidermal growth factor, increasing doses of CRISPP peptide enhanced DNA synthesis by 130%. In PHA-stimulated human peripheral lymphocytes, the CRISPP peptide increased DNA synthesis by 248%. >>>

Is Tobacco Use Finally Decreasing in France?

Annie J Sasco, M.D., Dr.P.H., Danielle Grizeau, B.S., Marc Danzon, M.D.

A national population survey of the adolescent and adult French population was conducted to evaluate trends in smoking behavior from 1977 to 1991. Smoking decreased in both sexes of adolescents from 46% in 1977 to 30% in 1991. In the adult population the overall rate was stable and although smoking decreased among men the trend was counterbalanced by an increase in women. >>>


Herbert E. Nieburgs, MD
Worcester, MA