Published in Cancer Detection and Prevention 1995; 19(1).

Risk factor interactions between fibrocystic breast disease and cancer with a special reference to diet

A Simard, J Vobecky, JS Vobecky

Faculte de medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7

Fibrocystic breast disease (FBD) has been extensively studied in order to identify the risk factors influencing its evolution towards malignancy. The nutritional factors were rarely documented as potential risk factors. In a case-control study of 334 women with FBD and of 340 matched controls, both selected among women participating at the National Breast Screening Program, the observed differences between these groups were examined with regard to the presence of known risk factors for breast cancer, especially those closely related to eating habits. Fat and vitamin E intakes were lower in FBD patients but high cholesterol intake (>300 g/day) was more frequent in controls. The logistic regression analysis suggested that vitamin E intake had a slightly protective effect and that age was an important risk factor for a malignant outcome.

Paper presented at the International Symposium on the Impact of Biotechnology on Predictive Oncology and Therapy; Boston, Massachusetts; December 11 - 13, 1994; in the section on Risk Factors & Diagnostic Markers.