Cancer Detection and Prevention Volume 18 / Issue 2 (Mar-Apr 1994)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

A Prospective Study of Endogenous Hormones and Breast Cancer

Kathy J. Helzlsouer , M.D., M.H.S., Anthony J Alberg, M.P.H., Ph.D., Trudy L. Bush, Ph. D. I Christopher Longcope, M. D., Gary B. Gordon, M. D., Ph.D., and George W. Comstock, M.D.

The relationship of high androstenedione levels and premenopausal breast cancer and the association of increased estradiol levels with postmenopausal breast cancer was not statistically significant. >>>

DNA Analysis in Advanced Breast Cancer

Maria Leivonen, M.D., Leena Krogerus, M.D., Stig Nordling, M.D.

Flow cytometry of archival material failed to give information on disease-free survival. It also had limited value as an independent prognostic factor after breast cancer recurrence. >>>

High c-erbB-2 Protein Level in Colorectal Adenocarcinomas Correlates with Clinical Parameters

Sanja Kapitanovic, M.D., Radan Spaventi, M.D., Ph.D., Ljiljana Poljak, M.D., Milan Kapitanovic, M.D., Zlatko P. Pavelic, M.D., Ph.D., Jack L. Gluckman, M.D., Sime Spaventi, M.D., Ph.D., and Kresimir Pavelic, M.D., Ph.D.

In the normal colon c-erbB-2 oncoprotein was weakly positive in 43% of the histologic sections. High levels of c-erbB-2 expression was found in dysplastic and villous adenomas, while in 50% of adenocarcinomas the levels were strongly positive. >>>

Alcohol Ingestion Enhances Hepatocarcinogenesis Induced by Synthetic Estrogen and Progestin in the Rat

Kentaro Yamagiwa, Ryuji Mizumoto, Shunsaku Higashi, Hiroyuki Kato, Takashi Tomida, Shin- ichi Uehara, Kanji Tanigawa, Minoru Tanaka, and Nobuhiro Ishida

The incidence of HCC and number of hyperplastic nodules in the rat liver, induced by 0.075 mg of ethynylestradiol and 6.0 mg norethidrone acetate, were increased by simultaneous treatment with 10% alcohol in drinking water. >>>

Gene Expression of Protein Phosphatases in Rat Ascites Hepatoma Cell Lines

Mostafa Saadat, M.SC., Kazuki Kitamura, M.SC., Yusuke Mizuno, D.SC., Hisaaki Saeki, M.D., Toshio Kudo, M.D., Kunimi Kikuchi, D.Med.SC.

Gene expression of protein phosphatases in rat ascites hepatoma (AH) cell lines was studied by Northern blot hybridization. Approximately 50% of AH cell lines had lower levels of PPI-,y-1 and PP2A-a in RNAs and 100% had lower levels of PP2C-a in RNA than the controls. >>>

p53 Gene in Hepatocellular Carcinomas From Australia

David A. Vesey, Ph.D., Nicholas K Hayward, Ph.D., and W Graham E. Cooksley, M.D.

The role of p53 gene mutations in the hepatogenesis of HCC in a country with low incidence of hepatitis B virus and aflatoxin exposure was assessed by direct sequencing following amplification with PCR. In 15 cases of HCC no mutation in exons 5 and 8 of the p53 gene were found. It is suggested that p53 in HCC development has a less important role in this particular of than in those of other areas. >>>

Intraoperative Ultrasonography of Liver: Detection of Occult Liver Tumors and Treatment by Cryosurgery

T. S. Ravikumar, M.D., F.A.C.S., Suzy Buenaventura, M.D., Ronald R. Salem, M.D., and Betsey D'Andrea, R.N.

In 110 patients undergoing liver surgery the usefulness of intraoperative ultrasonography for detection of occult liver tumors was demonstrated. >>>

Genetics, Prognosis and Therapy of Central Nervous System Tumors

David Watkins, Ph.D. and Guy A. Rouleau, M.D., Ph.D.

This review deals with the role of genetic disorders that may predispose the development of central nervous system tumors, and with their treatment by gene therapy. >>>

Melanoma in a Southeastern Hispanic Population

Lynn G. Feun, W. A. Raub, Jr., R. C. Duncan, Frederick Moffat, Niramol Savaraj, Albert Nemeth, Arnold Markoe, and Edward Trapido

An epidemiologic study of Hispanic patients with malignant melanoma revealed that most lesions occurred on the trunk, arm, shoulder, leg and hips. Survival with regional and distant disease was better in Hispanics than in non-Hispanics and 5-year survival was better in Hispanic females than Hispanic males. >>>

The Information Available From Swedish Data Systems Relevant to Evaluation of a Cancer Prevention Program in Stockholm County

Leif O.E Svanstrom, M.D., Ph.D., and Colin FB. Sanderson, M.Sc., Ph.D.

The objective of the Stockholm Cancer Prevention Program is the reduction of cancer incidence and of differences in incidence between socioeconomic groups. The program is expected to provide cancer registry data relevant to potential sources of cancer incidence and information on etiological relationships. >>>


Herbert E. Nieburgs, MD
Worcester, MA