Cancer Detection and Prevention Volume 18 / Issue 1 (Jan-Feb 1994)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

A New Tumor Promotion Pathway and its Inhibitors

Hirota Fujiki, M.D., Masami Suganuma, Ph.D., Atsumasa Komori, M.D., Jun Yatsunami, M.D., Sachiko Okabe, Tetsuya Ohta, B.S., Eisaburo Sueoka, M.D.

Okadaic acid class compounds induced tumor promotion through inhibition of protein phosphatase 1 and 2A while caventol inhibited tumor promotion of okadaic acid. Sarcophytol had anticarcinogenic activity in various rodent experiments. Patients consuming 10 or more cups per day of Japanese green tea containing mainly (-) epigallocatechin gallate had a decreased risk of developing gastric cancer. >>>

Poultry Oncogenic Retroviruses and Humans

Eric S Johnson, M.B., B.S., Ph.D.

In a comprehensive review of epidemiologic data it is suggested that the avian leukosis and sarcoma virus and the reticuloendotheliosis viruses may have carcinogenic potential for humans exposed to these viruses. Some epidemiological evidence points to an association between leukemia, lymphoma, brain tumors in human populations and chicken or egg production exposure. >>>

Nucleoprotein Complexes From Metastatic Cells Containing Oncogenes and Tissue-Specific Genes: A Novel Method to Track Genes Associated with Specific Nucleoproteins

Nancy L Rosenberg-Nicolson, Ph.D., Garth L Nicolson, Ph.D.

The dot-blot hybridization method localized the bcl-2 gene sequences to particular nucleoproteins isolated from nuclei of a chronic myelogenous leukemia patient. The technique described provides a tool for the study of binding properties and localization of a specific gene sequence to particular nucleoproteins at the subchromatin level. >>>

The Genetic Modification of T Cells for Cancer Therapy: An Overview of Laboratory and Clinical Trials

Patrick Hwu, Steven A Rosenberg

Tumor infiltrating lymphocytes were modified by transduction with the neomycin (Neo^R) resistance marker gene. Initial studies revealed that retroviral mediated gene transfer is a safe and practical method for the introduction of genes into humans. >>>

Familial Risk of Breast Cancer and Abortion

N Andrieu, F Clavel, B Gairard, L Piana, A Bremond, J Lansac, R Flamant, R Renaud

Abortions in women without a family history of breast cancer were not associated with a risk for breast cancer. In women with a family history of breast cancer, the highest risk was observed for those who had two or more either induced or spontaneous abortions. >>>

A Novel Approach to Estimate the Proportion of Hereditary Nonpolyposis Colorectal Cancer of Total Colorectal Cancer Burden

Lauri A Aaltonen, Risto Sankila, Jukka-Pekka Mecklin, Heikki Jarvinen, Eero Pukkala, Paivi Peltomaki, Albert de la Chapelle

Based upon the considerably lower age of diagnosis of patients with hereditary nonpolyposis colorectal cancer (HNPCC) than those with sporadic colorectal cancer (CRC), a cohort of 227 CRC patients aged 44 years and younger were chosen as probands. The results of this study suggest that the proportion of HNPCC of the total CRC burden is between 0.5 and 0.9 percent. >>>

Early Detection and Monitoring of Cancer with the Anti-Malignin Antibody Test

Martin B Abrams, Karl T Bednarek, Samuel Bogoch, Elenore S Bogoch, Herbert J Dardik, Richard Dowden, Stephen C Fox, Ernest E Goins, Gary Goodfried, Richard A Herrman, John Imperio, William Jackson, Stephen Keuer, M Killackey, Gary Kimel, Richard E Layton, A H. Liebentritt, David Marsden, James L. McCabe, M. Menasha, Kenneth Orten, Mark Pasmantier, T Pillai, VB Pillaj, Wayne Probst, William Reimer, Stanley Smith, Jerry Thomthwaite, William J Turner, Robert T Whitlock

The anti-malignin antibody (AMA) test was positive for early detection of cancer in 118 of 125 cases. Of the 56 patients who were monitored a correlation between the level of AMA and clinical status was 94.1 percent. >>>

Herbert E. Nieburgs, MD
Worcester, MA
1994