Published in Cancer Detection and Prevention 1993; 17(1).

Risk analysis of carcinogenesis in the remnant stomach of rats after oral administration of MNNG

Y Kitao, T Yarnane, A Okuyarna, K Oya, M Inagake, T Takahashi

First Dept of Surgery, Kyoto Prefectural Univ of Medicine, Kyoto 602, JAPAN

The promoted condition of the remnant stomach was examined in rats after oral administration of MNNG, using measurement of Ornithine Decarboxylase(ODC) activity of four groups, each of which were performed with the Billroth I method, the Billroth 11 method with/without Braun's anastomosis or gastrectomy as the control. ODC activity in the remnant stomach after each three types of operation was significantly high as compared to that in the stomach after the gastronomy. Guanosine Triphosphate(GTP) activated ODC activity after the Billroth 11 method without Braun's anastomosis was significantly higher than that of the other three groups. In conclusion, it was considered that the remnant stomach was under the highly promoted condition, especially after the Billroth 11 method without Braun's anastomosis.

Paper presented at the International Symposium on Cofactor Interactions and Cancer Prevention; Nice, France; March 17-19, 1993; in the section on Diagnostic Markers.