Published in Cancer Detection and Prevention 1993; 17(1).

Characteristic synthetic potential for sulfoglycosphingolipids in human endometrial adenocarcinoma

K Kubushiro, MD, J Tanaka, MD, K Kamei, MD, K Kiguchi, MD, S Nozawa, MD, Y Nagai, MD, M Iwamori, MD

Dept Obstetrics & Gynecology, Keio Univ School of Medicine. *Tokyo Metropolitan Institute of Medical Science. "Dept of Biochemistry, Faculty of Medicine, Univ of Tokyo. Tokyo, Japan

The expression of Sulfoglycosphingolipids is closely associated with cellular differentiation, proliferation, and abnormal expression of glycosphingolipids is detected in transformed cells. We analyzed the glycosphingolipids composition of human uterine endometrial adenocarcinoma in comparison with those of normal uterine endometrium. The amount of sulfoglycosphingolipids in endometrial adenocarcinoma is higher than those in proliferative phase of normal endometrium. Also, among cell lines established from gynecological cancers including cervical squamous carcinoma, endometrial adenocarcinoma, ovarian adenocarcinoma., choriocarcinoma, and vulvar melanoma, only those cells derived from endometrial adenocarcinoma expressed sulfoglycosphingolipids. Therefore, the unique sulfoglycosphingolipids are useful markers for the characterization of uterine endometrial adenocarcinoma among human gynecological cancers.

KEY WORDS: Uterine endometrial adenocarcinoma, Sulfoglycosphingolipids, Cell lines.

Paper presented at the International Symposium on Cofactor Interactions and Cancer Prevention; Nice, France; March 17-19, 1993; in the section on Diagnostic Markers.